Can I Take 5-htp and antidepressants Together?

SUMMARY:

Taking 5‑HTP together with antidepressants can increase serotonin activity and may raise the risk of serotonin syndrome; consult a prescriber before combining them.

ADDITIONAL NOTES:

Primary risk: excessive serotonergic activity (serotonin syndrome) when 5‑HTP is combined with serotonergic antidepressants. Highest risk with MAOIs; also a meaningful risk with SSRIs, SNRIs, TCAs, and other serotonergic agents. Symptoms to watch for: agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, tremor, muscle rigidity, hyperreflexia, shivering, sweating, and high fever — seek urgent care if these occur. Practical points: avoid starting 5‑HTP while on an MAOI; if a clinician permits combined use with SSRIs/SNRIs/TCAs, use the lowest effective dose, monitor closely, and beware of variable dosing/quality in supplements. Do not stop prescribed antidepressants without medical advice.