Can I Take acetaminophen and excedrin Together?

SUMMARY:

Taking acetaminophen together with Excedrin causes duplicate acetaminophen exposure and increases the risk of exceeding the recommended total daily acetaminophen dose, which can lead to liver injury.

ADDITIONAL NOTES:

Many Excedrin formulations already contain acetaminophen (plus other ingredients such as aspirin and caffeine). Using additional acetaminophen while taking Excedrin raises total acetaminophen intake and increases risk of hepatotoxicity—especially with frequent use, higher doses, or concurrent alcohol use. Watch for signs of liver injury (nausea, vomiting, abdominal pain, dark urine, yellowing of skin/eyes). Check product labels for acetaminophen content and consult a pharmacist or clinician before combining products or if unsure about total dosing.