Can I Take diphenhydramine and alcohol Together?

SUMMARY:

Combining diphenhydramine with alcohol can produce additive central nervous system depression, increasing drowsiness, dizziness, impaired coordination, and in higher doses potentially slowed breathing; avoid alcohol while taking diphenhydramine, especially when driving or operating machinery.

ADDITIONAL NOTES:

Both are CNS depressants and their effects are additive. Expect increased sedation, impaired thinking and motor skills, and greater fall risk—particularly in older adults. There is also an increased risk of respiratory depression when combined with other depressants (opioids, benzodiazepines, sleep medications). Seek urgent care if you experience severe drowsiness, difficulty breathing, fainting, or confusion.