Can I Take st johns wort and antidepressants Together?
SUMMARY:
Taking St. John's wort together with prescription antidepressants can be risky: it may raise the chance of serotonin syndrome with serotonergic antidepressants and can alter blood levels of many antidepressants by inducing liver metabolism. Avoid combining them or change doses only under a clinician’s supervision.
ADDITIONAL NOTES:
Main risks: 1) Serotonin syndrome when combined with SSRIs, SNRIs, TCAs, MAOIs or other serotonergic drugs — watch for agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, tremor/rigidity, sweating, and fever. 2) Enzyme induction (e.g., CYP systems) by St. John's wort can lower plasma concentrations of many antidepressants and other drugs, reducing effectiveness or causing withdrawal/relapse. Interaction severity varies by specific antidepressant; some combinations may be particularly unsafe. Do not start, stop, or change doses of St. John's wort or antidepressants without consulting a prescriber or pharmacist.
MEDICAL DISCLAIMER
The information provided on this page is for general educational and informational purposes only. It is not intended as, and should not be considered, medical advice, diagnosis, or treatment.
This information has not been evaluated by the Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease.
Always consult with a qualified healthcare provider before taking any medication or supplement, especially if you are pregnant, nursing, have a medical condition, or are taking other medications.
IMPORTANT LIMITATIONS:
- This tool does not list all possible drug interactions
- The absence of a listed interaction does not mean the combination is safe
- Information may not be current, complete, or accurate for your specific situation
- Individual factors (age, weight, health conditions, genetics) affect interactions
- Always verify with your pharmacist or healthcare provider
In case of emergency, call 911 or your local emergency services immediately.
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CanITakeThis.com - General educational information only. Not medical advice.