Can I Take berberine and metformin Together?

SUMMARY:

Taking berberine together with metformin can produce additive blood‑glucose lowering and may increase the risk of hypoglycemia; monitoring of blood sugar and symptoms is recommended.

ADDITIONAL NOTES:

Both berberine and metformin lower blood glucose, so combined use can increase hypoglycemia risk—especially if you are also on insulin or sulfonylureas. Both agents commonly cause gastrointestinal side effects (nausea, diarrhea), which may be worse when taken together. Metformin carries a rare risk of lactic acidosis in patients with reduced kidney function; using additional glucose‑lowering supplements should be done cautiously if renal impairment is present. Berberine may affect some drug‑metabolizing enzymes and transporters, but major pharmacokinetic interactions with metformin are not well established. Monitor blood glucose closely, check renal function as advised, and consult a healthcare provider before starting or combining these agents.