Can I Take acetaminophen-phenylephrine-dextromethorphan with acetaminophen?

SUMMARY:

These two preparations both contain acetaminophen; using them together can increase total acetaminophen exposure and raise the risk of liver injury if the combined dose exceeds recommended limits. Avoid taking both at once or carefully check total daily acetaminophen to stay below recommended maximums and consult a healthcare provider if unsure.

ADDITIONAL NOTES:

The combination product contains acetaminophen in addition to phenylephrine and dextromethorphan, so taking it with a separate acetaminophen product causes duplicate acetaminophen dosing. Excess acetaminophen can cause hepatotoxicity, especially in people who drink alcohol regularly, have pre-existing liver disease, or take other hepatotoxic drugs. Typical adult maximum limits are commonly cited in the 3,000–4,000 mg/day range; exceeding these increases risk. Watch for symptoms of liver injury (nausea, abdominal pain, jaundice, dark urine) and review product labels or consult a clinician or pharmacist before combining products.