Can I Take acetaminophen with naproxen?

SUMMARY:

These two drugs are commonly used together for short-term pain or fever relief and generally have no major direct drug–drug interaction when taken at recommended doses.

ADDITIONAL NOTES:

Naproxen is an NSAID (anti-inflammatory) and acetaminophen is an analgesic/antipyretic; taking them together can provide additive pain relief without a pharmacokinetic interaction. Main risks to watch for: NSAID-related gastrointestinal bleeding, cardiovascular risks with long-term NSAID use, and kidney stress (risk increased with dehydration or pre-existing kidney disease); acetaminophen carries a risk of liver injury if doses exceed the recommended maximum. Use caution if you are on anticoagulants (increased bleeding risk) or have liver or kidney disease; avoid exceeding the labeled acetaminophen dose (commonly 3–4 g/day for adults depending on product and guidelines), limit prolonged NSAID use, and consult a clinician for chronic or high-dose use.