Can I Take probiotics with antacids?

SUMMARY:

Probiotics and antacids are generally considered compatible for most people; no serious direct interaction is expected. Antacids can change stomach acidity and may theoretically alter the survival or effectiveness of some probiotic strains, but clinically significant problems are uncommon.

ADDITIONAL NOTES:

Antacids (including OTC neutralizers, H2 blockers, and proton pump inhibitors) raise gastric pH, which can increase or decrease survival of particular probiotic strains depending on formulation; this is usually not clinically significant for typical use. There are no widely reported serious adverse interactions, but caution is advised for people with severe immune compromise or central venous catheters because rare infections have been reported with probiotics. If concerned about probiotic viability, follow product instructions or consider spacing doses (for example, separate dosing by ~2 hours) or using an enteric-coated probiotic as recommended by the product or a clinician.