Can I Take xanax with diphenhydramine?

SUMMARY:

Combining alprazolam (Xanax) with diphenhydramine commonly increases drowsiness, dizziness, confusion, and difficulty concentrating because both depress the central nervous system. This combination can impair coordination and thinking and raises fall and accident risk, especially in older adults.

ADDITIONAL NOTES:

Alprazolam is a benzodiazepine and diphenhydramine is a sedating first‑generation antihistamine; their effects are additive. Potential risks include excessive sedation, cognitive and motor impairment, increased fall risk in the elderly, and possible respiratory depression at high doses or when combined with other depressants (e.g., alcohol, opioids). Avoid driving or operating machinery until you know how the combination affects you, and discuss dose adjustments or safer alternatives (non‑sedating antihistamines) with a prescriber or pharmacist.