Can I Take ibuprofen with tylenol pm?

SUMMARY:

These two medicines are generally safe to take together at typical OTC doses: ibuprofen (an NSAID) plus Tylenol PM (acetaminophen + diphenhydramine) have no major direct drug–drug interaction, but watch dosing and specific risks. Monitor total daily acetaminophen, NSAID risks (stomach, kidney, blood pressure), and diphenhydramine-related sedation especially in older adults.

ADDITIONAL NOTES:

- Drug classes: ibuprofen = NSAID; Tylenol PM = acetaminophen (analgesic/antipyretic) + diphenhydramine (sedating antihistamine). - No significant pharmacologic interaction between ibuprofen and acetaminophen/diphenhydramine when used at recommended doses. - Acetaminophen risk: avoid exceeding recommended daily limit (generally ≤3–4 g/day depending on guidance); caution with liver disease or regular alcohol use. - Ibuprofen risks: GI bleeding, stomach ulcers, kidney injury, and blood pressure elevation — caution in the elderly, those with kidney disease, heart disease, or on blood thinners. - Diphenhydramine risks: drowsiness, impaired coordination, anticholinergic effects (dry mouth, urinary retention, confusion) — especially problematic in older adults or when combined with other sedatives or alcohol. - Practical advice: follow dosing labels, avoid taking other products that contain acetaminophen, avoid alcohol, and consult a healthcare provider if pregnant, breastfeeding, or if you have chronic medical conditions or take other regular medications.