SUMMARY:
No clinically significant interaction is reported between melatonin and magnesium at typical doses; the combination is generally considered likely safe for most people.
ADDITIONAL NOTES:
No major drug–drug interaction identified. Both agents can cause or contribute to drowsiness/somnolence in some individuals (possible mild additive effect). Magnesium supplements can cause GI upset (diarrhea) and may accumulate in people with significant kidney impairment — use caution and consult a provider if you have renal disease or take other medications. If you experience excessive sedation or other concerning symptoms, stop and seek medical advice.
MEDICAL DISCLAIMER
This information is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before making any changes to your supplement or medication regimen. Drug interactions can vary based on individual health conditions, dosages, and other factors.
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